N ‐arachidonoyl glycine suppresses Na + / Ca 2+ exchanger‐mediated Ca 2+ entry into endothelial cells and activates BK Ca channels independently of GPCR s
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چکیده
منابع مشابه
N-arachidonoyl glycine suppresses Na+/Ca2+ exchanger-mediated Ca2+ entry into endothelial cells and activates BKCa channels independently of GPCRs
BACKGROUND AND PURPOSE N-Arachidonoyl glycine (NAGly) is a lipoamino acid with vasorelaxant properties. We aimed to explore the mechanisms of NAGly's action on unstimulated and agonist-stimulated endothelial cells. EXPERIMENTAL APPROACH The effects of NAGly on endothelial electrical signalling were studied in combination with vascular reactivity. KEY RESULTS In EA.hy926 cells, the sustained...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2013
ISSN: 0007-1188,1476-5381
DOI: 10.1111/bph.12180